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Acetylcarnitine, the shortest metabolite of a class of fatty acid metabolites called acylcarnitines and one of the most abundant blood metabolites in humans can be used as a dietary/nutritional supplement with proven clinical efficacy in the treatment of MDD, ME/CFS and other neuropsychiatric disorders

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One observational study involving data from 135 migraine patients indicated treatment with folic acid was more effective than conventional treatment for reducing pain scores in carriers of the MTHFR mutation (Guo 2022)

Usually it comes in capsule or liposomal form

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