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While lactate has been reported to promote ferroptosis in normal cellular contexts by modulating iron homeostasis and lipid peroxidation, tumor cells appear to exploit lactate signaling pathways to reinforce their anti-ferroptotic defenses

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10.1016/j.bbr.2020.112919 Summary Keywords retina, ischemia, BPC 157, L-NAME, rats Citation Zlatar M, Kokot A, Vuletic LB, Masnec S, Kralj T, Perisa MM, Barisic I, Radic B, Milanovic K, Drmic D, Seiwerth S and Sikiric P (2021) BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats