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A triple combination targeting epigenetic dysregulation and apoptotic resistance, comprising iadademstat (LSD1 inhibitor), azacitidine (a hypomethylating agent), and venetoclax (a BCL-2 inhibitor), is under investigation in a phase I trial for acute myeloid leukemia (NCT06357182)
Treatment begins with 0.25 mg administered subcutaneously once weekly for four weeks, serving primarily as a tolerance-building dose rather than a therapeutic one
Some patients prefer this, especially if they have recent labs from their primary care provider
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1992;281(Pt 2):31723
These devices represent a leap forward from the traditional syringe-and-needle approach, providing a less invasive method of drug delivery
