Although there have been no head-to-head trials yet, tirzepatide could potentially lead to more significant weight loss with a comparable safety profile to semaglutide, according to an article in Frontiners in Endocrinology
2 68% of patients were at very high risk for CKD progression 2,k Patient characteristics at baseline (N=3533) 1,2 k Patients were classified as very high risk for CKD progressing according to Kidney Disease: Improving Global Outcomes (KDIGO) risk calculators based on GFR and albuminuria categories
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A patient considering a GLP-1 drug should be able to answer these questions honestly before starting: Has a qualified endocrinologist or physician evaluated my overall metabolic health, not just my weight
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Exposures included semaglutide [25, 26, 28] and the overall GLP-1RA class [27, 29]