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Because of the low frequency of SIS outcomes and their potential severity, and based on our estimates, we cannot rule out either a threefold increase or a decrease in SIS rates among people with type 2 diabetes and obesity treated with GLP-1RA

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Lower cost does not automatically mean higher risk

Blaszczuk A, Baranska A, Kanadys W, et al

However, a larger randomized controlled trial in patients with type 2 diabetes at the same dose didnt find significant changes in insulin sensitivity or glycemic control

Randomized Controlled Trial of Semaglutide for Alcohol Use Disorder In a randomized controlled Phase 2 trial of semaglutide for alcohol use disorder (AUD), Christian Hendershot at UNC / USC found significant reductions in drinking among people taking semaglutide, particularly in reducing heavy drinking days