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Additionally, CSCs actively contribute to the remodeling of the TME by secreting various metabolites, thereby creating a favorable ecological environment for tumor initiation and progression (74)
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Archived from the original on July 23, 2012
Pickart and colleagues (Biomed Res Int, 2015) published a comprehensive genome-wide analysis documenting effects on DNA repair pathways (with multiple repair-enzyme genes upregulated, including those involved in nucleotide excision repair and base excision repair), anti-oxidant systems (modulation of superoxide dismutase, catalase, and glutathione-related genes), matrix-remodeling pathways (collagen, elastin, and proteoglycan synthesis enzymes), and inflammatory pathway markers
It circulates in your blood plasma, shows up in your saliva, and appears in your urine
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