Emily Cooper, Mark Wright, and Andrea Taylor answer listener questions about BMI cutoffs, weight cycling, metabolic adaptation, trauma, GLP-1 differences, and why some people gain weight on ultra-low calories
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Nolen-Doerr says he may recommend moving to a higher dose of the oral medication
This lower-dose strategy can improve medication tolerability and minimize gastrointestinal discomfort
NF-B regulates genes involved in cell proliferation (Cyclin D1), anti-apoptosis (e.g., survivin and the inhibitor of apoptosis protein), anti-cancer drug resistance (MDR1), cancer metastasis (e.g., COX-2 and MMP9), and immunomodulation (Takada et al., 2005)