Fatigue or tiredness is another common complaint
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The calorie math: In practice, the actual weight loss is lower than the pure calorie calculation predicts, because the body partially compensates by increasing appetite and reducing energy expenditure
It is unclear whether the efficacy of oral semaglutide or other GLP-1RAs is impacted by metformin in the presence of another insulin and other glucose-lowering background medications
Diabetic Medicine: a Journal of the British Diabetic Association 22(10):13431346 Kwon S, Kim YC, Kwon H, Cho JH, Kim CD, Son HE, Jeong JC, Jung IM, Yoo KD, Kim Y, Lee W (2023) Metformin use and long-term clinical outcomes in kidney transplant recipients
GLP-1s do not relieve stress or treat the underlying stressors. It is possible that GLP-1s can help suppress emotional eating: Esposito says that the feeling of fullness they provide could make overeating in response to emotional stress less desirable