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Statements Author contributions All authors contributed to the article and approved the submitted version

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

The temporary "bridge" program is administered by the Centers for Medicare & Medicaid Services (CMS) and is scheduled to run through December 31, 2027

If recommended by your provider, basic lab work can help establish your current kidney function and mineral levels before you start medication

The anti-inflammatory gene regulation adds another dimension