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Estrogens, including E2, also promote hippocampal plasticity (5053) through several possible actions (54), including through its actions on spinogenesis (55), and inflammation in the hippocampus (56) in female rodents
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The deficiency of DHEA in inflammatory diseases also implies a deficiency in peripheral tissue of various sex hormones for which DHEA serves as a precursor
Without structure, most patients backslide
Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time
Bourdon and Blache, 2001
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