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They are contraindicated in patients with renal impairment manifested by hypercreatininemia and reduction of glomerular filtration rate

Zhao, H., Eguchi, S., Alam, A

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In addition, partial oxygen pressure in RPE is high due to anatomical proximity to choriocapillaries 5,6,7

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In a recent study, treatment with liraglutide significantly reduced oxidative stress induced by high glucose levels