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Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting

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The main practical warning: when the drug is injected mixed in plain water or saline, it can cause pain or tissue damage at the injection site

This linguistic overlap is precisely why the FDA issued warnings about dosing errors with compounded semaglutide

PMC+1 Further, their original authorisation and indication were for glucose-controlnot for long-term, standalone obesity treatment