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Dosing, cost, and when to choose each one
2010 May;72(4):357-364
doi:10.36849/JDD.6550 Samantha Ouellette BA, Giulia Frias BA, Radhika Shah MD PharmD, Mahin Alamgir MD, Cindy Wassef MD Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of antidiabetic agents that work by inducing insulin secretion and inhibiting release of glucagon in a glucose-dependent manner
The Lys-34 to Arg-34 substitution is structurally subtle but functionally critical: it removes the native lysine at position 34, ensuring that the fatty-acid moiety attaches selectively to Lys-26 and not to the alternative position
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However, in older adults with obesity refractory to lifestyle strategies, pharmacotherapy, using anti-obesity medicines (AOMs), can be a useful adjunct
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