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Among them, C1-27 was one of the most potent GSTO1 inhibitors (Fig

A smaller subset just under one-third experienced both benefits: reduced fibrosis and resolved inflammation

However, further research in humans is still needed to confirm its effectiveness.

The decrease is approximately 150 kcal per day less than predicted by standard metabolic models, suggesting GLP-1 medications partially protect against the severe metabolic slowdown seen with dieting alone