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Acknowledgements This work was supported by the National Key R&D Program of China (2023YFC2705802 to J.W.), the National Natural Science Foundation of China (82573812 to C.C.), the Natural Science Foundation of Hubei Province (2025AFB580 to C.C.), the Foundation of Tongji Hospital, China (2023CXZH014 and 25-2KYC13057-18 to C.C.), and the China Postdoctoral Science Foundation (2025M782382 to M.X.)
Adding MOTS-C to an AOD 9604 stack targets mitochondrial function and cellular energy metabolism
Initial results reported that phase I metabolism of the nootropic was very low with an intrinsic clearance of 2.72 ul/min/mg, as well as an average half life of approximately 510 minutes
It attaches to environmental toxins like pesticides, toxic metals and alcohol making them more water soluble and therefore able to be excreted
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