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Symptoms of glutathione synthetase deficiency may include: Seizures Hampered reaction to speech and physical stimuli Poor coordination Intellectual disability Vulnerability to bacterial infections Low glutathione levels are also associated with a large number of disorders, including some types of cancer and AIDS

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IV repletion is used in clinical practice as part of protocols for NAFLD, NASH, alcoholic liver disease, viral hepatitis B and C, heavy metal and environmental toxin exposure, mold toxicity protocols, and post-acetaminophen toxicity recovery

It modulates GABA and serotonin systems involved in pain processing

Glutathione is made in the cytosol of the cell by two enzymes

Article PubMed Google Scholar Wilding, J