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Transdermal routes often struggle with penetration in a predictable way

However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food

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Injectable Peptides Most peptides are poorly absorbed when taken orally because digestive enzymes and stomach acid break them down before they can reach the bloodstream

doi: 10.1016/J.IJBIOMAC.2024.129651 48 El-FawalG

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