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Furthermore, HIF-1 depletion impacted glucose consumption and uptake, as well as glycolytic gene expression in the same setting (Fig

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As a result, SASP can propagate widely and contribute to tissue dysfunction, including chronic inflammation, fibrosis, and the progression of neurodegenerative diseases (Nelson et al., 2012)

In a previous study by Fukuda's lab, the researchers showed Rap1 in the VMH helps regulate blood glucose and energy balance in mice

This review will compare the two modes of signal transduction and propose an evolutionary model of a partnership of the two mechanisms in the eukaryotic cell, with redox-mediated signals being more specific and ancestral and phosphorylative signals being more diffuse but predominant in signal propagation