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M-HT: Conceptualization, Methodology, Project administration, Resources, Supervision, Writing original draft, Writing review & editing
Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1
Reinhold AK, Rittner HL
Melatonin is the downstream hormone secreted by the pineal gland that directly signals sleep onset, with effects measurable within hours via the suprachiasmatic nucleus
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