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Studies have detected increased expression of senescence markers, including the cell cycle inhibitors p 16INK4a and p21 Cip1 , reduced levels of Lamin B1, and positive staining for SA--Gal activity in endometriotic lesions or stromal cells derived from these lesions or patients with endometriosis [105]
Zippo A, Serafini R, Rocchigiani M, Pennacchini S, Krepelova A, Oliviero S
Investigated in endocrine system regulation
Farfn M, lvarez A, Grate A, Bouchon P
Some experimental results suggest significant increases in circulating IGF-1, which is thought to act as a downstream mediator of growth hormone activity
nausea, diarrhea, vomiting, constipation, bloating)
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