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Abd El Aziz MS, Kahle M, Meier JJ, Nauck MA

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IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1

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doi:10.1056/NEJMoa2301972 [3] Coskun T, Urva S, Roell WC, et al

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