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Notably, adaptive therapy prolonged the time to progression to at least 27 months compared with approximately 16.5 months under standard dosing, while reducing cumulative drug exposure by nearly half

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Sci Signal 8 , ra27, 10.1126/scisignal.aaa0899 (2015)

Lithium is the drug that most qualifies to fulfil the term a mood stabiliser with a proven effect in mania, possibly bipolar depression [7], and prevention of manic as well as depressive episodes [35-38]