When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
The Clinic Takeaway: What AOD 9604 Means for South Florida Patients AOD 9604 is not a weight loss miracle
Poor planning leads to inconsistent use
By inhibiting NNMT, 5-Amino-1MQ appears to improve how the body handles glucose
At HyperCharge Health, we lead in personalized care, including this therapy and others like hormone optimization, weight loss, peptides, IV infusions, and more
This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates