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Cholesterol accumulation impairs HIF-1-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway

Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

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