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Depleted glutathione by NAPQI leads to increased H 2 O 2 release that oxidizes thioredoxin and induces the disassociation of thioredoxin from apoptosis signalling-regulating kinase 1 (ASK-1), triggering self-activation of ASK-1, which phosphorylates mitogen-activated protein kinase kinase 4/7 and activates c-Jun N-terminal kinase (JNK) (Hanawa et al., 2008
Thanks to the large bathochromic shift accompanying the reaction, the peak of the excess of the derivatization reagent does not appear on the chromatogram 32
Effect of L-carnitine supplementation on xenobiotic-metabolizing hepatic enzymes [PMID: 16616465] Laboratory literature summary: Effect of L-carnitine supplementation on xenobiotic-metabolizing hepatic enzymes exposed to methanol
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Alliance 3 , e201900502 (2020)
The role of in vivo and ex vivo diagnostic tools in severe delayed immune-mediated adverse antibiotic drug reactions
