MC4R activation in the hypothalamus and brainstem drives appetite suppression and energy expenditure
GLP-1s were associated with lower risk of complications for those already having a substance use disorder Among people who already had a substance use disorder, starting a GLP-1 medication was associated with fewer substance-related emergency department visits, hospital admissions, overdose events, episodes of suicidal ideation or attempts, and lower mortality (see graph below)
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During these studies, side effects were assessed in a diverse group of participants, including 262 participants on placebo, 260 on 0.5 mg, and 261 on 1 mg
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