Liraglutide and semaglutide are available in the UK and the U.S
Body composition tracking via DEXA or other methods quantifies muscle gain and fat loss
Based on current clinical evidence: Mounjaro (tirzepatide) Wegovy (semaglutide 2.4 mg) Ozempic (semaglutide) Semaxa (oral semaglutide) However, individual responses vary considerably
In STEP-1 (semaglutide), lean mass decreased by ~9.7% while fat mass fell by ~19.3%, with the proportion of lean mass increasing by ~3 percentage points ( Limited preclinical and clinical data, particularly from MRI-based studies, suggest that skeletal muscle changes induced by GLP-1RAs may be adaptive
Shanley DP, Aw D, Manley NR, Palmer DB (2009) An evolutionary perspective on the mechanisms of immunosenescence
Phase 2 dose-finding trial Published in The Lancet in 2021, this multicenter, randomized, double-blind trial tested cagrilintide doses ranging from 0.3 mg to 4.5 mg weekly in people with overweight or obesity