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To ascertain the obesity-specific role of TMPRSS2 in regulating postprandial glucose homeostasis, we employed an independent preclinical model of obesity (db/db mice) and performed a pharmacological intervention with a TMPRSS2 inhibitor
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RECOVER will also allocate additional funding for an ongoing trial of baricitinib, a Janus kinase (JAK) inhibitor made by Eli Lilly and Company thats approved to treat alopecia and rheumatoid arthritis
More specifically it has been posited to regulate the cellular actin-cytoskeleton and cellular migration by sequestering G-actin
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