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First, increased collagen fills in the surface irregularities that create wrinkle appearance
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Kumar N, Surani S, Udeani G, Mathew S, John S, Sajan S, et al
FIGURE 6 2.5 Skin fibrosis Hypertrophic scar is a prevalent yet inadequately resolved fibrotic dermatological condition, presenting as elevated, erythematous, indurated, and non-elastic plaques ( The pathogenesis of systemic sclerosis (SSc) is associated with endothelial damage, fibroproliferative vasculopathy, and fibroblast dysfunction (Taflinski et al., 2014
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