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The MHRA advises checking B12 levels if deficiency is suspected and considering periodic monitoring in at-risk patients, whilst generally continuing metformin therapy during investigation and treatment

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This means that nerve cells in the brain are not working well

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In a notable phase II clinical trial published in The Lancet (2008), Tesofensine demonstrated dose-dependent weight loss of up to 10.6% over 24 weeks in obese individualssubstantially higher than placebo or many existing weight-loss drugs