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Wang, J., et al

Side Effects of Zofran Zofran, or ondansetron, is a medication commonly used to prevent nausea and vomiting

Activation of the 2 -adrenergic pathway is the main mechanism by which insulin secretion is inhibited by the SNS 21 hence our strategy was to activate 2 adrenergic receptors on pancreatic -cells to test if this would counteract the hypothesised decrease in SNS activity triggered by OB GLP-1R activation in WD mice

An elegant data analysis of the STEP-2 protocol shows the temporal dynamic of this effect, where the incidence of nausea grew from ~5% at the beginning of the dose escalation period (week 1

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