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At the same time, the pleiotropic, neurotrophic and neuroprotective properties of GLP-1RAs are also obvious and, taking into account the ability to enhance the energy metabolism of neurons and optimize synaptic plasticity these beneficial effects position GLP-1RAs as potential agents modifying brain diseases [109, 110]
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For obesity trials, however, it can miss a crucial question: Where are the patients actually located
In 2024, Novo generated roughly half its revenue from GLP-1s, while Ely Lilly earned $10.4 billion of its $15.6 billion total revenue from key products, illustrating that despite its broad pipeline, Eli Lilly is becoming more concentrated in its commercial performance of these key drugs
