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[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe

Oral supplements are available in various forms in the market, for example: tablets, capsules, and sublingual (under the tongue) formulations

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Larger pack configurations (10-vial, 25-vial, bulk 25500) are available but the vial size itself is consistently 10 mL across all SKUs