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In the Lancet 2021 Phase 2 trial at 4.5 mg/week, nausea occurred in 47% of participants, injection-site reactions in 43%, constipation in 21%, and vomiting in 8%

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This observation suggests that additional regulatory mechanisms, such as post-translational modification, may be required for gasdermin D-mediated cell death in these contexts 66,67,68