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Are You on a GLP-1

One potential explanation is group heterogeneity, in this case an inclusion of participants with different biological backgrounds despite similar clinical presentations, which might lead to a decrease in power to detect changes, especially if these are subtle

Possible side effects include stomach pain, allergic reactions, and constipation

Friedman does not directly dispense these compounds

Liraglutide has the longest GLP-1 safety record, having been approved for diabetes in 2010 and for weight management in 2014, but its average weight loss is lower than the newer agents

These observations suggest that the timing of metformin administration can potentially substantially influence its efficacy for postprandial glucose-lowering, and that the current recommendation (at least for the immediate-release preparation) that people with type 2 diabetes should take metformin with meals may compromise its benefits