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Alternating between semaglutide and tirzepatide on a weekly or monthly basis may prevent the receptor desensitization that contributes to stalls on either medication alone
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The SURMOUNT-1 trial demonstrated up to 22.5% body weight reduction with tirzepatide at the highest dose (15mg weekly), compared to semaglutide's 14.9% in STEP 1
The effect measures estimated were relative risk (RR) for dichotomous data, and weighted mean difference (WMD) for continuous data, using 95% confidence intervals (CIs)
others use a risk-adjusted discount rate that reflects litigation probability, regulatory risk, and IRA negotiation exposure
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