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Independent studies have reported increased oxidative stress and altered ETC activity (120) and decreased levels of antioxidants and antioxidant enzymes (121) in the brain tissue of patients with depression
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However, its effectiveness appears to be more pronounced in injected forms for gastrointestinal conditions 4
Mechanistic insights from the REMODEL trial further support its role, identifying improvements in renal microvascular function through reduction of kidney fat, improved glomerular hemodynamics, attenuation of endothelial injury via metabolic reprogramming, and decreased inflammation and fibrosis
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