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However, in vitro, evidence suggests that hyperglycemia, a primary metabolic feature of T2DM, can lead to impaired GLP-1 secretion and L-cell differentiation

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The overaccumulation of triacylglycerol and cholesterol in the hepatocytes and the overproduction of reactive oxygen species (ROS) both lead to local inflammatory responses

AMPK-deficient mice exhibit splenomegaly due to accumulation of eryptotic RBCs and severe anemia, and their erythrocytes are prone to enhanced eryptosis [149]

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