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Niacin can also cause bloating, burping, facial redness, and increased gas

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Subcutaneous adipose tissue in the buttocks is not vascular enough to deliver enough methyl-B12 fast enough to produce a significant clinical response in such a short period of time

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Irish journal of medical science, 193 (3), 16211639

Altered B12 handling and reduced clearance in kidney disease, and both cellular release and reduced clearance in liver disease, can raise B12, so supportive renal or hepatic findings make those causes plausible