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People who participated in Contrave clinical trials started to lose weight at the 4-week mark

Important caveat: every claim above comes from cell-culture or animal studies of the individual peptides

300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats

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The small sample size of the GLP-1RA, however, limits generalizability, and baseline BMI differences may have influenced the observed outcomes