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2 h pretreatment followed by 12 h cadmium exposure) inhibits the activation of JNK/p38 MAPK and PI3K/Akt signaling pathways in cadmium-treated cells by downregulating the expression of pro-apoptotic markers and normalizing the Bax/Bcl-2 ratio

Anisimov VN, Bondarenko LA, Khavinson VKh

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These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

Most gastrointestinal events were classified as mild to moderate, and the majority were transient, resolving within the first several weeks of treatment or after dose stabilization