Whos at risk of deficiency
Target IGF-1 increases of 40-100 ng/mL from baseline indicate appropriate dosing for most anti-aging and optimization goals, while smaller increases suggest underdosing or poor pituitary reserve requiring escalation or alternative approaches
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Readers who wish to consider the two building blocks separately should read the dedicated monographs to avoid cannibalizing the concepts: CJC-1295 guide and Ipamorelin guide
Studies show that PPC supplementation can lower liver enzyme levels and improve ultrasound results in people with fatty liver disease in doses of 900-1,800mg/day.12 17 For general prevention, simply meeting the AI (425-550mg/day elemental choline) through diet or modest supplements is protective.1 Pregnancy & lactation Choline is critical for fetal brain development and a mothers milk supply.46 Most prenatals contain little or none, and over 90% of pregnant women fall short of the AI.1 40Experts advise aiming for 450-550mg/day, but one Cornell clinical trial showed that 930mg/day in late pregnancy produced infants with faster processing speeds than 480mg/day.1 47 Extra supplementation may be warranted
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