The use of GLP-1, initially introduced to reverse or treat type 2 diabetes, has become the tool du jour for weight management
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A phase 2 trial published in JAMA Psychiatry found that adults with alcohol use disorder taking low-dose semaglutide experienced: Fewer heavy drinking days Reduced overall alcohol consumption, even without attempts to quit Decreased cravings, confirmed through self-reported logs and laboratory tests Behavioral changes are also evident: participants drink less often, consume fewer drinks per occasion, and experience less pleasure from alcohol
Again though, the effects in this regard are likely to be moderate or even clinically insignificant
Incretin-based drugs are now being investigated and in some cases approved for a wide range of conditions, including cardiovascular disease, neurodegenerative disorders, and even substance use disorder
Besides tracking the results of RCTs and anticipating the release of national and international guidelines, eye care practitioners can utilize current knowledge