FXR deficiency enhances plasma GLP-1 levels in response to colonic SCFA supply in HFD-fed mice To assess whether inhibition of FXR could enhance SCFA-induced GLP-1 secretion in vivo , HFD-fed WT and FXR KO mice were supplemented with inulin-type fructans (ITF) (300 mg/mouse/day) which are known to increase the supply of microbiota-derived SCFAs to colonic L-cells and to improve energy homeostasis 32,33
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Inspect the solution: Before injecting, examine the Ozempic solution in the pen