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The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

When those junctions are compromised, by NSAIDs, alcohol, chronic stress, or repeated antibiotic courses, the result is a low-grade inflammatory state that shows up as bloating, systemic fatigue, food sensitivities, and immune dysregulation

A key hypothesis we are studying here is that in endometriosis, a pro-oxidant microenvironment in the local vicinity of the follicle created by an unbalanced redox state detrimentally impacts the quality of oocytes, sperm, and embryos, hampering their cellular function, jeopardizing their viability, and that this is a fundamental underlying cause of diminished fertility with endometriosis

Additionally, leveraging NRF2 activation can bolster cellular antioxidant defenses, further mitigating the pathological effects of ferroptosis

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At non-toxic concentrations of 1 to 10 nM, the peptide stimulates in preclinical models both the synthesis and the breakdown of collagen and glycosaminoglycans such as dermatan and chondroitin sulfate as well as decorin, and it modulates matrix metalloproteinases together with their inhibitors TIMP-1 and TIMP-2