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Kazi reported grants from the National Heart, Lung, and Blood Institute, American Heart Institute, Agency for Healthcare Research and Quality, Patient-Centered Outcomes Research Institute, and Institute for Clinical and Economic Research outside the submitted work

After 48 h, biofilms were washed once with 1 PBS and treated using one of the following: 30 mM GSH or 4 g/mL amikacin individually or a combination of 30 mM GSH + 4 g/mL amikacin

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Glutathione is small peptide molecules produced by the liver and made up of three amino acids

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione