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Los frmacos que imitan su accin (agonistas del receptor GLP-1 como la semaglutida o la liraglutida, y, en el caso de tirzepatida, un agonista dual GIP/GLP-1) han ganado popularidad por su eficacia en control glucmico y reduccin de peso , siempre bajo prescripcin y seguimiento mdico

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This might explain the common x axis intercept in LineweaverBurk plots 11,17,18 , which resemble a non-competitive inhibition pattern with identical dissociation constants for the inhibitor and substrate 52

Another, slightly modified synthetic version of exendin-4, lixisenatide (112), was subsequently launched and designated for once daily use, but in fact the actions and pharmacokinetics of the two peptides are identical

& Marchioni, D