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In addition to being important to the whole cell for folate metabolism, it is essential for maintaining mitochondrial function in the mitochondria
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2.2 Challenges in oral delivery of macromolecules Despite its protective role, the intestinal epithelial barrier presents a major obstacle to oral delivery of macromolecular therapeutics, particularly proteins and peptides
Hydration status: Nausea and reduced oral intake can lead to dehydration, potentially causing acute kidney injury, particularly in older adults
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