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Metformin's most common side effects are gastrointestinal and include nausea, diarrhea, abdominal discomfort, and metallic taste
Importantly, GLP-1 receptor agonists are not recommended for patients with severe gastrointestinal disease, including gastroparesis, as they may worsen symptoms
This is not a medical recommendation
Several ingredients have plausible mechanisms
Several GLP-1 RAs are now licensed for the treatment of type 2 diabetes
For an injectable biologic, competition from biosimilars produces a slope rather than a cliff a gradual erosion over years rather than months
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