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The primary difference lies in their mechanism of action
This coating protects the glutathione from breakdown in the stomach, allowing it to reach and pass through the intestinal wall intact
The traditional classification of microglial phenotypes into binary M1 (pro-inflammatory) and M2 (anti-inflammatory/neuroprotective) categories has provided a useful conceptual framework, though it is increasingly recognized as an oversimplification of their functional diversity (Figure 5)
Previous studies have demonstrated that gut-derived GLP-1 activates vagal sensory nerves, triggering insulin secretion via brain-autonomic nervous system pathways, a mechanism referred to as the "neuro-incretin effect" [51, 59]
5.2 Acute Pancreatitis Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including WEGOVY [see Adverse Reactions (6)]
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